Biological analyses traditionally probe cell ensembles, thereby completely averaging over relevant individual cell responses, such as differences in cell proliferation, responses to external stimuli or disease onset.
Increasing interest has therefore evolved for single cell analytical methods, which could give exciting new insights in genomics, proteomics, transcriptomics and systems biology.
The review article by T.-C. Chao & A. Ros describes the pros and cons of microfluidic or lab-on-a-chip devices for single cell analysis and summarizes the developments and achievements for the analysis of intracellular compounds of single cells, from proof of principle microfluidic devices to applications demonstrating high biological relevance.
Journal of the Royal Society Interface
Journal of the Royal Society Interface is the Society's cross-disciplinary publication promoting research at the interface between the physical and life sciences. It offers rapidity, visibility and high-quality peer review and is ranked fifth in JCR's multidisciplinary category. The journal also incorporates Interface Focus, a peer-reviewed, themed supplement, each issue of which concentrates on a specific cross-disciplinary subject.
Journal of the Royal Society Interface
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